anti-DGCR8 phospho (Ser377) antibody

Arigo Biolaboratories

anti-DGCR8 phospho (Ser377) antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

DDC

dopa decarboxylase

AADC; aromatic-L-amino-acid decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase)

Rabbit

IgG

Phosphorylated

The Drosha-DGCR8 microprocessor complex is required for microRNA (miRNA) biogenesis. DGCR8 (DiGeorge Syndrome Critical Region 8) recognizes the RNA substrate, whereas Drosha functions as the endonuclease. DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains, interacts with the pri-miRNA and functions as the molecular anchor that measures the distance from the ds-RNA-ssRNA junction and directs Drosha cleavage 11bp away (Han J et al, 2006). The efficiency of Drosha cleavage increases in the presence of heme and promotes the formation of highly ordered DGCR8 structures upon binding to RNA (Faller et al, 2010).

Human

-20°C

12352203