Bio-Connect

Anti-Digoxin [26 / 10]

Research Use Only
Ab00494-10.7
Absolute Antibody
ApplicationsELISA, RadioImmunoAssay
Product group Antibodies
ReactivityPlant
Price on request
Packing Size
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-Digoxin [26 / 10]
  • Delivery Days Customer
    7
  • Antibody Specificity
    The antibody binds digoxin with an affinity (Kd) of 9 nM.
  • Application Supplier Note
    The antibody is specific for digoxin, a cardiac glycoside derived from the foxglove plant. Digoxin is administered for the therapeutic treatment of heart conditions such as atrial fibrillation, atrial flutter and heart failure, an acts by inhibiting the Na+/K+ ATPase. However, the drug has a very narrow therapeutic index and can cause toxic side effects. The Fab fragment prepared from 26-10 that neutralises the activity of digoxin and can be used as an antidote in case of overdose of digitalis. Anti-digoxin monoclonal antibodies can also be used to measure serum levels of the drug as a guide to therapy, and are useful in the investigation of the kinetics of interaction between antibody and antigen.
  • Applications
    ELISA, RadioImmunoAssay
  • Applications Supplier
    ELISA; RIA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    26 / 10
  • Host
    Human
  • Scientific Description
    This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
  • Reactivity
    Plant
  • Reactivity Supplier
    Digitalis lanata
  • Reactivity Supplier Note
    Spleen cells from A/J mice immunized with digoxin coupled to human serum albumin (Dig-HSA).
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203