Anti-DLL3 [SC16.25]

Absolute Antibody

Anti-DLL3 [SC16.25]

7

This antibody binds human DLL3 in the N-terminal domain. Cross-reacts with cynomolgus monkey DLL3 with no binding to mouse/rat DLL3. Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligan

The binding characterization of this antibody to human DLL3 was done using ELISA. Binding affinity of mouse IgG antibody for human DLL3 is Kd= less than 0.2 nM. This antibody can bind human and cynomolgus monkey DLL3 expressed on surface of 293 cells via flow cytometry. This antibody can mediate killing of tumor cells expressing DLL3. Humanized version of this antibody is also available on request (US9089615).

Functional Assay, Flow Cytometry, ELISA

ELISA; FC; functional assay

Research Use Only

Monoclonal

SC16.25

DLL3

delta like canonical Notch ligand 3

delta3; delta-like 3; delta-like protein 3; drosophila Delta homolog 3; SCDO1

Mouse

IgG1

Delta-like protein 3

Human, Monkey

Human, Cynomolgus monkey

The original antibody was generated by immunizing three strains of mice (Balb/c, CD-1 and FVB) with recombinant human DLL3-Fc or with human DLL3-His fusion constructs.

-20°C,2°C to 8°C

12352203