anti-DMPK antibody
ARG10650
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Canine, Equine, Guinea Pig, Human, Mouse, Rat
TargetDMPK
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-DMPK antibody
- Delivery Days Customer23
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.5-1 mg/ml
- ConjugateUnconjugated
- Gene ID1760
- Target nameDMPK
- Target descriptionDM1 protein kinase
- Target synonymsDM; DM protein kinase; DM1; DM1PK; DMK; dystrophia myotonica protein kinase; MDPK; MT-PK; myotonic dystrophy associated protein kinase; myotonin protein kinase A; myotonin-protein kinase; thymopoietin homolog
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3 untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
- ReactivityBovine, Canine, Equine, Guinea Pig, Human, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203