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anti-DNA PKcs antibody

Research Use Only
ARG54085
Arigo Biolaboratories
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetPRKDC
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-DNA PKcs antibody
  • Delivery Days Customer
    23
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Concentration
    2.3 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5591
  • Target name
    PRKDC
  • Target description
    protein kinase, DNA-activated, catalytic subunit
  • Target synonyms
    DNA-dependent protein kinase catalytic subunit; DNAPK; DNA-PK catalytic subunit; DNAPKc; DNA-PKC; DNA-PKcs; DNPK1; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; IMD26; p350; p460; protein kinase, DNA-activated, catalytic polypeptide; XRCC7
  • Host
    Mouse
  • Isotype
    IgG2b
  • Scientific Description
    Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage.Involved in DNA nonhomologous end joining(NHEJ)required for double-strand break(DSB)repair and V(D)J recombination.Must be bound to DNA to express its catalytic properties.Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis(DCLRE1C).The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step.Required to protect and align broken ends of DNA.May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage.Found at the ends of chromosomes,suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion.Also involved in modulation of transcription.Recognizes the substrate consensus sequence[ST]-Q.PhosphorylatesSer-139 of histone variant H2AX/H2AFX,thereby regulating DNA damage response mechanism.Phosphorylates DCLRE1C,c-Abl/ABL1,histone H1,HSPCA,c-jun/JUN,p53/TP53, PARP1, POU2F1,DHX9,SRF,XRCC1,XRCC1,XRCC4,XRCC5,XRCC6,WRN,MYC and RFA2.Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA.Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203