anti-Dnmt3L antibody [S117-9]
ARG22285
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetDNMT3L
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-Dnmt3L antibody [S117-9]
- Delivery Days Customer23
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDS117-9
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID29947
- Target nameDNMT3L
- Target descriptionDNA methyltransferase 3 like
- Target synonymscytosine-5-methyltransferase 3-like protein; DNA (cytosine-5-)-methyltransferase 3-like; DNA (cytosine-5)-methyltransferase 3-like; human cytosine-5-methyltransferase 3-like protein
- HostMouse
- IsotypeIgG1
- Scientific DescriptionCpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203