anti-DOK1 / p62 Dok phospho (Tyr362) antibody
ARG20529
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetDOK1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-DOK1 / p62 Dok phospho (Tyr362) antibody
- Delivery Days Customer23
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1796
- Target nameDOK1
- Target descriptiondocking protein 1
- Target synonymsdocking protein 1; Downstream of tyrosine kinase 1; P62DOK; pp62
- HostRabbit
- Scientific DescriptionDoks are a family of adaptor proteins that include six Dok proteins (Dok1 to Dok6), which have an N-terminal pleckstrin homology domain, a central phosphotyrosine binding domain, and a C-terminal region containing multiple tyrosine residues. When phosphorylated, these tyrosines can serve as docking sites for SH2 domain-containing proteins. Dok1 (p62dok) has been shown to bind Ras-GAP, Nck, and Csk. Several tyrosine phosphorylation sites have been identified for Dok1. One site, Tyr-362 (Tyr-361 mouse), is phosphorylated by c-Abl, is required for Nck binding, and may be critical for filopodia formation during fibroblast spreading on fibronectin. Alternatively, Dok1 activity is also regulated by serine phosphorylation. IkappaB Kinase beta phosphorylates several serine sites including Ser-450 in vitro, and TNFalpha, IL-1, and radiation treatment lead to phosphorylation of Ser-443, Ser-446, and Ser-450 in vivo. Phosphorylation of these serine sites may be required for Dok-mediated inhibition of MAPK signaling and stimulation of cell motility.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203