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anti-DOK1 / p62 Dok phospho (Tyr362) antibody

ARG20529
Arigo Biolaboratories
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetDOK1
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-DOK1 / p62 Dok phospho (Tyr362) antibody
  • Delivery Days Customer
    23
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID1796
  • Target name
    DOK1
  • Target description
    docking protein 1
  • Target synonyms
    docking protein 1; Downstream of tyrosine kinase 1; P62DOK; pp62
  • Host
    Rabbit
  • Scientific Description
    Doks are a family of adaptor proteins that include six Dok proteins (Dok1 to Dok6), which have an N-terminal pleckstrin homology domain, a central phosphotyrosine binding domain, and a C-terminal region containing multiple tyrosine residues. When phosphorylated, these tyrosines can serve as docking sites for SH2 domain-containing proteins. Dok1 (p62dok) has been shown to bind Ras-GAP, Nck, and Csk. Several tyrosine phosphorylation sites have been identified for Dok1. One site, Tyr-362 (Tyr-361 mouse), is phosphorylated by c-Abl, is required for Nck binding, and may be critical for filopodia formation during fibroblast spreading on fibronectin. Alternatively, Dok1 activity is also regulated by serine phosphorylation. IkappaB Kinase beta phosphorylates several serine sites including Ser-450 in vitro, and TNFalpha, IL-1, and radiation treatment lead to phosphorylation of Ser-443, Ser-446, and Ser-450 in vivo. Phosphorylation of these serine sites may be required for Dok-mediated inhibition of MAPK signaling and stimulation of cell motility.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203