anti-Dopamine Transporter phospho (Thr53) antibody

Arigo Biolaboratories

anti-Dopamine Transporter phospho (Thr53) antibody

23

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Slc6a3

solute carrier family 6 member 3

DA transporter; DAT; Dat1; sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter), member 3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Rabbit

IgG

Phosphorylated

The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinsons disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). Levels of DAT protein expression are altered by chronic drug administration (Wilson et al., 1996). It has been shown that phosphorylation at Thr53 directly affects dopamine influx and amphetamine-stimulated substrate efflux, indicating that the Thr53 residue plays a major role in transport activity (Foster et al., 2012).

Rat

-20°C

12352203