Anti-DR4 [T1014G03 ]

Absolute Antibody

Anti-DR4 [T1014G03 ]

9

This antibody binds human CD261 (TR4 or TRAILR1 or TNFRSF10A). This protein acts as a receptor for the cytotoxic ligand TNFSF10/TRAIL and transduces cell death signal and induces cell apoptosis.

The binding specificity of this antibody to human TR4 (CD126) fusion protein was determined using ELISA. This antibody does not cross react with other proteins like TR7, TR5, TR10 and BLyS. It was reported that the scFv version of the antibody binds human TR4 fusion protein with a binding affinity of Kd= 5.54 x 10^(-10) nM. It was also reported that when administered with in vivo Topotecan, this antibody was capable of retarding the growth of tumor cells in nude mice (US7064189).

ELISA, Other Application

Research Use Only

Monoclonal

T1014G03

TNFRSF10A

TNF receptor superfamily member 10a

APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a

Human

IgG1

Tumor necrosis factor receptor superfamily member 10A

Human

-20°C,2°C to 8°C

12352203