Anti-DR5 [PRO95780 (Drozitumab)]

Absolute Antibody

Anti-DR5 [PRO95780 (Drozitumab)]

9

This antibody is specific for human death receptor 5, a proapoptotic receptor widely expressed in adult and fetal tissues, with notably high expression on tumour cells. Activation of DR5 triggers apoptosis in various types of cancer cells, without affecti

This antibody binds DR5, triggering DR5 clustering and DISC activation in a range of cancer cells, including colorectal cancer and NSCLC cells (Adams, 2009). Conversely, this antibody showed no effector caspase activation or cell death induction in normal human hepatocytes. In vivo, this antibody has been shown to inhibit tumor xenograft growth in a variety of animal models (Varfolomeev, 2009). This antibody was used in IP, immunoblot, ELISA and IF analysis to precisely characterise its interaction with the DR5 ligand (Adams, 2009).

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, Other Application

Research Use Only

Monoclonal

PRO95780 (Drozitumab)

TNFRSF10B

TNF receptor superfamily member 10b

apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; CD262; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; death receptor 5; DR5; Fas-like protein; KILLER; KILLER/DR5; p53-regulated DNA damage-inducible cell death receptor(killer); TNF-related apoptosis-inducing ligand receptor 2; TRAILR2; TRAIL-R2; TRICK2; TRICK2A; TRICK2B; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; ZTNFR9

Human

IgG1

Tumor necrosis factor receptor superfamily member 10B

Human

-20°C,2°C to 8°C

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