anti-Drebrin antibody [DBN-N-03] (PE)

Arigo Biolaboratories

anti-Drebrin antibody [DBN-N-03] (PE)

23

Flow Cytometry

Research Use Only

Monoclonal

DBN-N-03

RPE

DBN1

drebrin 1

D0S117E; developmentally-regulated brain protein; drebrin; drebrin A; drebrin E; drebrin E2

Mouse

IgG2b

Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimers disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.

Human

2°C to 8°C

12352203