Anti-E Cadherin [56-4]

Absolute Antibody

Anti-E Cadherin [56-4]

7

The binding of this antibody to mouse E-cadherin results in its activation. The initial binding characterization of this antibody to mouse E-cadherin was done using ELISA. This antibody was used to study the effect of activation of mouse E-cadherin on the growth and metastasis of a spontaneous breast cancer mouse model. Female MMTV-PyMT and control mice treated with 5 mg/kg of this antibody developed tumors in all 10 mammary glands. Also the number of metastasis nodules was significantly reduced with treatment with 56-4 activating antibody (PMID: 32127478; WO2020243616).

ELISA, Other Application

agonist; ELISA

Research Use Only

Cadherin-1

-20°C,2°C to 8°C

12352203