Anti-E-protein [DV22]

Absolute Antibody

Anti-E-protein [DV22]

9

This antibody recognises domain I and II of the envelope (E) protein of DENV4 only, shown by ELISA and Western blot.

DV22 has been used in cell-based assays and was shown to exhibit neutralisation and antibody-dependent enhancing activity using Vero and K562 cells (Beltramello et al, 2010). This antibody has also been characterised as EDI/II-specific by ELISA and Western blot. When generated as a LALA variant and supplied as a cocktail with two other anti-DENV mAbs, DV22 showed a complete lack of antibody-dependent enhancement (ADE) activity, whilst retaining the ability to neutralise DENV infection.

Flow Cytometry, Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

DV22

Human

IgG1

This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203