Anti-E2 [10B5 (RS10B5huFc) ]

Absolute Antibody

Anti-E2 [10B5 (RS10B5huFc) ]

9

This antibody binds the E2 envelope polyprotein of the Western equine encephalitis virus (WEEV), which is a mosquito-borne arbovirus (arthropod-borne virus) and the causative agent of western equine encephalitis (WEE). WEEV belongs to the genus Alphavirus

This antibody can bind the WEEV E2 envelope glycoprotein in an ELISA. The human Fc domain of the antibody was capable of effector functions, such as binding to protein G and human complement (PMID: 10768836). This antibody was found to possess a binding affinity to a WEE virus epitope (K[D] = 9.14 x (10)^-6 M). This antibody was also reported to not cross react with other alphaviruses like Sindbis virus [SIN], Venezuelan equine encephalitis [VEE] virus, and eastern equine encephalitis [EEE] virus. Pharmacokinetics studies showed that the RS10B5huFc antibody (free and encapsulated) was found to be retained in the lungs of mice for greater than 48 h when administered intranasally. In contrast, when administered intramuscularly to mice, the RS10B5huFc antibody was not detected in the lungs and only found in the liver and kidneys (PMID: 11289221).

ELISA

Research Use Only

Monoclonal

10B5 (RS10B5huFc)

Rabbit

IgG

Structural polyprotein

Virus

-20°C,2°C to 8°C

12352203