anti-eIF2 beta phospho (Ser2) antibody

Arigo Biolaboratories

anti-eIF2 beta phospho (Ser2) antibody

23

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

EIF2S2

eukaryotic translation initiation factor 2 subunit beta

EIF2; EIF2B; EIF2beta; eIF-2-beta; eukaryotic translation initiation factor 2 subunit 2; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; PPP1R67; protein phosphatase 1, regulatory subunit 67

Rabbit

IgG

Phosphorylated

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Human

-20°C

12352203