Anti-Envelope glycoprotein gp160 [0.5beta], Mouse IgG2b, Fc Silent(tm), kappa

Absolute Antibody

Anti-Envelope glycoprotein gp160 [0.5beta], Mouse IgG2b, Fc Silent(tm), kappa

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This antibody is specific forth V3 loop of the envelope glycoprotein gp160.

The original version of this antibody was used for an ELISA on a synthetic 20 amino acid peptide (308-327) based on the sequence of the RP135 region of gp120 from HIV-IIIB (Maeda et al., 1991; PMID:1873503). This antibody was used for a western blot on HTLV-IIIB antigens (Matsushita et al., 1988; PMID:2452899), and on Purified HTLV-IIIB (Skinner et al., 1988; PMID:2456088). The NMR structure of this antibody was determined (Tugarinov et al., 2000; PMID:10801487). The ability of this antibody to neutralize a cell-free HIV infection of H9 cells was assayed. It was indeed able to prevent this infection (Matsushita et al., 1988; PMID:2452899). This antibody was also able to neutralize the HIV infection of AA-5 cells (Skinner et al., 1988; PMID:2456088). This antibody was able to prevent HIV infection in chimpanzees in vivo (Emini et al., 1992; PMID:1741059).

Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

0.5beta

Mouse

IgG2b

Envelope glycoprotein gp160

This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse IgG2b format, created for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203