Anti-Envelope protein (soluble) [Z23]

Absolute Antibody

Anti-Envelope protein (soluble) [Z23]

9

Z23 binds to the ZIKV soluble envelope (sE) protein, shown using ELISAs, SPR and kinetic competition assays (Wang et al, 2016). This mAb is highly specific for ZIKV, and was shown to exhibit no neutralisation activity against DENV-1 to DENV-4 virions, whi

Z23 was confirmed to bind ZIKV sE protein by ELISA, with an affinity of 0.44 uM shown by SPR (Wang et al, 2016). Using a FACS-based assay, it was shown that Z23 potently neutralised viral activity against infected C6/36 and Vero cells. In vivo, Z23 completely protected IFN receptor KO mice from ZIKV infection.

Flow Cytometry, ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

Z23

Human

IgG4

This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203