Anti-EPHA3 [FA225-C10]

Absolute Antibody

Anti-EPHA3 [FA225-C10]

9

This antibody is specific for EPHA3.

This antibody is a humanized affinity improved version of the original mouse parental antibody IIIA4. The binding affinity of this antibody for EphA3 antigen was determined by ELISA. Flow cytometry was performed with this antibody on cells from patients with multiple myeloma (US20110243934). In the xenograft model of leukemia the antibody directly affects the tumor cells with no effect on stromal and vascular elements. In human tumor xenografts of prostate cell line DU-145 in nude mice, FA225-C10 antibody produced a significant inhibition of tumor growth. In this model the tumor cells do not express EphA3 but the tumor stroma and neovasculature express EphA3 and treatment with antibody reduced both tumor stroma and new vessel density (Charmsaz et al., 2014).

Flow Cytometry, ELISA

Research Use Only

Monoclonal

FA225-C10

EPHA3

EPH receptor A3

EK4; EPH-like kinase 4; eph-like tyrosine kinase 1; ephrin type-A receptor 3; ETK; ETK1; HEK; HEK4; human embryo kinase 1; testicular tissue protein Li 64; TYRO4; TYRO4 protein tyrosine kinase; tyrosine-protein kinase receptor ETK1

Rabbit

IgG

Ephrin type-A receptor 3

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203