Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-ER-alpha Rabbit Monoclonal Antibody (Clone RM292) at a 1:100 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-ER-alpha Rabbit Monoclonal Antibody (Clone RM292) at a 1:100 dilution.
anti-ER alpha (human), Rabbit Monoclonal (RM292)
REV-31-1176-00
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetESR1
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-ER alpha (human), Rabbit Monoclonal (RM292)
- Delivery Days Customer5
- Antibody SpecificityThis antibody reacts to reacts to human ER-alpha (Estrogen receptor).
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM292
- FormulationLiquid
- Gene ID2099
- Target nameESR1
- Target descriptionestrogen receptor 1
- Target synonymsE2 receptor alpha; ER; Era; ER-alpha; ESR; ESRA; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; ESTRR; NR3A1; nuclear receptor subfamily 3 group A member 1; oestrogen receptor alpha
- HostRabbit
- IsotypeIgG
- Protein IDP03372
- Protein NameEstrogen receptor
- Scientific DescriptionEstrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 Estrogen receptor-alpha (ER-alpha) isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer and osteoporosis. - Recombinant Antibody. This antibody reacts to reacts to human ER-alpha (Estrogen receptor). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 Estrogen receptor-alpha (ER-alpha) isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer and osteoporosis.
- ReactivityHuman
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203