Anti-Erythropoietin receptor [Ab198]

Absolute Antibody

Anti-Erythropoietin receptor [Ab198]

9

RIA showed that Ab198 competes with EPO for binding to EPO-R. SPR determined the Kd of Ab198 binding to EPO-R as 13.9 nM. In an EPO dependent human cell proliferation assay Ab198 stimulated proliferation of the F36E cell line. Ab198 also induced proliferation of human erythroid producing cells derived from progenitor cells in a dose-dependent manner. In a cynomolgus bone marrow CFUe assay Ab198 induced the formation of CFU-E colonies.

Other Application, RadioImmunoAssay

Research Use Only

Monoclonal

Ab198

EPOR

erythropoietin receptor

EPO-R; erythropoietin receptor; truncated erythropoietin receptor

Human

IgG1

Erythropoietin receptor

This reformatted human antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203