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anti-EWSR1 / EWS antibody [5H7]

ARG11128
Arigo Biolaboratories
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman
TargetEWSR1
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-EWSR1 / EWS antibody [5H7]
  • Delivery Days Customer
    23
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5H7
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2130
  • Target name
    EWSR1
  • Target description
    EWS RNA binding protein 1
  • Target synonyms
    bK984G1.4; Ewing sarcoma breakpoint region 1; Ewings sarcoma EWS-Fli1 (type 1) oncogene; EWS; EWS RNA-binding protein variant 6; EWS-FLI1; RNA-binding protein EWS
  • Host
    Mouse
  • Isotype
    IgG2b
  • Scientific Description
    This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203