Anti-Factor VIII A2 domain [BOIIB2]

Absolute Antibody

Anti-Factor VIII A2 domain [BOIIB2]

9

This antibody binds the A2 domain of the human factor VIII, a glycoprotein involved in blood coagulation. Factor VIII acts as a cofactor for factor IXa which converts factor X to the activated form Xa in the presence of calcium and phospholipids. Defects

The binding specificity and epitope characterization of this antibody was determined using ELISA. The ability of this antibody inhibit factor VIII function in vitro was studied using a chromogenic functional assay. It was reported that this antibody inhibited the conversion of factor X to factor Xa at concentration of 0.1 microg/ml. It was found that this antibody inhibits thrombin production using both the intrinsic and extrinsic pathway of coagulation (US20080206254).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

BOIIB2

F8

coagulation factor VIII

AHF; antihemophilic factor; coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIIIc; DXS1253E; F8B; F8C; factor VIII F8B; FVIII; HEMA

Rabbit

IgG

Coagulation factor VIII

Human

-20°C,2°C to 8°C

12352203