anti-FAM129B phospho (Ser679 / Ser683) antibody

Arigo Biolaboratories

anti-FAM129B phospho (Ser679 / Ser683) antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

NIBAN2

niban apoptosis regulator 2

bA356B19.6; C9orf88; FAM129B; family with sequence similarity 129 member B; MEG-3; melanoma invasion by ERK; MINERVA; niban-like protein 1; OC58; protein Niban 2

Rabbit

IgG

Phosphorylated

FAM129B, also known as Niban-like protein 1, belongs to a poorly characterized protein family with unknown category and function. Increased expression of the Niban gene has been observed in renal carcinomas (Adachi et al., 2004; Sun et al., 2007). Suppression of FAM129B expression in HeLa cells has been seen to promote apoptosis, suggesting that it can modulate cell death signaling, and may be involved in the ER stress response (Sun et al., 2007). FAM129B is also up-regulated in various types of thyroid tumors and Hashimotos thyroiditis (Matsumoto et al., 2006). It has been suggested that the MAP kinase dependent phosphorylation of FAM129B is important in controlling melanoma cells, as inhibition of B/Raf/MKK/ERK in melanoma cells represses invasion (Old et al., 2009). It is believed that phosphorylated FAM129B not only derepresses invasion, but also regulates events that promote invasion (Old et al., 2009).

Human, Primate

-20°C

12352203