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anti-FEN1 antibody

Research Use Only
ARG54167
Arigo Biolaboratories
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetFEN1
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-FEN1 antibody
  • Delivery Days Customer
    23
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Concentration
    1.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2237
  • Target name
    FEN1
  • Target description
    flap structure-specific endonuclease 1
  • Target synonyms
    DNase IV; FEN-1; flap endonuclease 1; maturation factor-1; MF1; RAD2
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    Structure-specific nuclease with 5-flap endonuclease and 5-3 exonuclease activities involved in DNA replication and repair.During DNA replication,cleaves the 5-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5-end of a downstream Okazaki fragment.It enters the flap from the 5-end and then tracks to cleave the flap base,leaving a nick for ligation.Also involved in the long patch base excision repair (LP-BER) pathway,by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions.Also possesses 5-3 exonuclease activity on nicked or gapped double-stranded DNA,and exhibits RNase H activity.Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203