anti-FEN1 antibody

Arigo Biolaboratories

anti-FEN1 antibody

23

ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

1 mg/ml

Unconjugated

FEN1

flap structure-specific endonuclease 1

DNase IV; FEN-1; flap endonuclease 1; maturation factor-1; MF1; RAD2

Mouse

IgG1

Structure-specific nuclease with 5-flap endonuclease and 5-3 exonuclease activities involved in DNA replication and repair.During DNA replication,cleaves the 5-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5-end of a downstream Okazaki fragment.It enters the flap from the 5-end and then tracks to cleave the flap base,leaving a nick for ligation.Also involved in the long patch base excision repair (LP-BER) pathway,by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions.Also possesses 5-3 exonuclease activity on nicked or gapped double-stranded DNA,and exhibits RNase H activity.Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Human

-20°C

12352203