Anti-FGF1 [1C9]

Absolute Antibody

Anti-FGF1 [1C9]

9

This antibody binds the human FGF-1.

FGF-1 plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Studies have shown that FGF-1 is overexpressed in the early stages of several kinds of cancer. Functional analysis showed that the overexpressed scFv1C9 in MCF-7 cells targeted endogenous FGF-1 and prevented the translocation of FGF-1 into the nucleus, resulting in the blockade of the intracrine pathway of FGF-1, which caused the G1 arrest by p21 up-regulation. Binding of scFv1C9 to FGF-1 was confirmed with ELISA. The antigen-binding ability of scFv1C9 with endogenous FGF-1 was confirmed in vivo by using of an immunoprecipitation assay. FGF-1 immunohistochemical staining of breast ductal carcinoma tissues was used to to demonstrate that FGF-1 was increasingly expressed in breast cancer tissues.(PMID:21360642).

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Monoclonal

1C9

FGF1

fibroblast growth factor 1

AFGF; beta-endothelial cell growth factor; ECGF; ECGFA; ECGFB; ECGF-beta; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; FGF-1; FGFA; FGF-alpha; fibroblast growth factor 1; fibroblast growth factor 1 (acidic); GLIO703; HBGF1; HBGF-1; heparin-binding growth factor 1

Human

IgG1

Fibroblast growth factor 1

This full-length, chimeric human antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203