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ProductsBack/Anti-FGF1 [1C9]

Anti-FGF1 [1C9]

Research Use Only
Ab02035-30.11
Absolute Antibody
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-FGF1 [1C9]
  • Delivery Days Customer
    7
  • Application Supplier Note
    FGF-1 plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Studies have shown that FGF-1 is overexpressed in the early stages of several kinds of cancer. Functional analysis showed that the overexpressed scFv1C9 in MCF-7 cells targeted endogenous FGF-1 and prevented the translocation of FGF-1 into the nucleus, resulting in the blockade of the intracrine pathway of FGF-1, which caused the G1 arrest by p21 up-regulation. Binding of scFv1C9 to FGF-1 was confirmed with ELISA. The antigen-binding ability of scFv1C9 with endogenous FGF-1 was confirmed in vivo by using of an immunoprecipitation assay. FGF-1 immunohistochemical staining of breast ductal carcinoma tissues was used to to demonstrate that FGF-1 was increasingly expressed in breast cancer tissues.(PMID:21360642).
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry
  • Applications Supplier
    ELISA; IP; WB; IHC; IF
  • Certification
    Research Use Only
  • Protein IDP05230
  • Protein Name
    Fibroblast growth factor 1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203