Anti-FGFR2 Rabbit mAb

PTM BIO

Anti-FGFR2 Rabbit mAb

5

ImmunoHistoChemistry Paraffin

IHC-P

Antibody

Research Use Only

Monoclonal

JRMR-250

Unconjugated

Rabbit

IgG

Fibroblast growth factor receptor 2

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylatedrylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylatedrylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203