Anti-Folate receptor beta [CL10]

Absolute Antibody

Anti-Folate receptor beta [CL10]

9

The antibody binds specifically to FRbeta, a member of the folate receptor family. The receptor binds with high affinity to folic acid and folic acid derivatives, and transports 5-methyltetrahydrofolate into the cell. The receptor is expressed on the surface of tumour associated macrophages (TAMs) that promote growth and metastasis of tumours such as gliomas and colon, breast and lung carcinomas. Research has shown FRbeta is only expressed on activated macrophages, and thereby a monoclonal antibody that targets the receptor can be useful in the diagnosis of the cancer. Furthermore, the antibody may be conjugated with a toxin, delivering the drug only to TAMs and not to healthy macrophages.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

CL10

Folr2

folate receptor 2 (fetal)

FBP; FBP2; Fol; folate binding protein 2; folate receptor beta; Folb; Folbp2; Folbp-2; FR-; FR-beta; FR-P3

Mouse

IgG2a

Folate receptor beta

This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203