Anti-FOLR2 Alexa Fluor(r) 647

EXBIO

Anti-FOLR2 Alexa Fluor(r) 647

7

The mouse monoclonal antibody EM-35 recognizes an extracellular epitope on FOLR2, a 30-40 kDa cell surface protein serving as a receptor for folic acid.

Flow cytometry: Recommended dilution: 0.2-4 microg/ml.

Flow Cytometry, Western Blot, ImmunoCytoChemistry

Research Use Only

EM-35

0.1 mg/ml

AlexaFluor 647

IgG1

FOLR2 (folate receptor beta) is a cell surface protein that was originally thought to be specific for placenta, but it can be also expressed in other tissues, including hematopoietic cells. Its expression is increased in malignant tissues. FOLR2 may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. FOLR2 is a marker for macrophages generated in the presence of M-CSF (M2), including M2-like tumor-associated macrophages, which exert potent immunosuppressive functions within the tumor environment, but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability.

Human, Mouse

2°C to 8°C

12352203