anti-FOXP3 antibody [3G3]

Arigo Biolaboratories

anti-FOXP3 antibody [3G3]

23

Flow Cytometry, Western Blot

Research Use Only

Monoclonal

3G3

1 mg/ml

Unconjugated

>95%

Foxp3

forkhead box P3

forkhead box protein P3; JM2; scu; scurfin; scurfy; sf

Mouse

IgG1

FoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.

Mouse

-20°C

12352203