Anti-GABA-A Receptor, Gamma 2 Subunit [10F10-C1-B8]

Absolute Antibody

Anti-GABA-A Receptor, Gamma 2 Subunit [10F10-C1-B8]

9

This antibody was generated against amino acids 37-53 of rat GABA-A receptor gamma2 subunit (GABRG2) and is specific for the N-terminal extracellular domain, allowing for the detection of surface expressed receptors for live imaging. GABA-A receptors are

In the original study, this antibody was used in Western Blot assays, immunohistochemistry (IHC) and immunoprecipitate (IP) for identification of the gamma2 subunit from rat and mouse hippocampal proteins (Joshi et al., 2011). This antibody could also be used in functional studies, for example, to show that the GABA-A receptor membrane insertion rates are specified by their subunit composition (Joshi et al, 2013), to delineate how chorein deficiency leads to upregulation of gephyrin and GABAA receptor (Kurano et al., 2006), to examine the homeostatic strengthening of inhibitory synapses as mediated by the accumulation of GABAA receptors (Rannals et al., 2011), and to demonstrate that NMDA receptor activation downregulates expression of delta Subunit-containing GABA-A receptors in cultured hippocampal neurons (Joshi et al. 2013).

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

10F10-C1-B8

Gabrg2

gamma-aminobutyric acid type A receptor subunit gamma 2

GABA(A) receptor subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid receptor subunit gamma-2; gamma-aminobutyric acid type A receptor gamma 2 subunit

Mouse

IgG1

Gamma-aminobutyric acid receptor subunit gamma-2

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Rat

-20°C,2°C to 8°C

12352203