anti-GABAA Receptor alpha 5 antibody

Arigo Biolaboratories

anti-GABAA Receptor alpha 5 antibody

23

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Polyclonal

Unconjugated

Gabra5

gamma-aminobutyric acid type A receptor subunit alpha 5

GABA(A) receptor subunit alpha-5; GABA-A receptor alpha-5 subunit; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5; gamma-aminobutyric acid type A receptor alpha 5 subunit

Rabbit

IgG

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Poeltl et al., 2003).

Bovine, Canine, Chicken, Human, Mouse, Primate, Rat, Zebra Fish

-20°C

12352203