anti-GABAA Receptor beta 3 phospho (Ser408 / Ser409) antibody

Arigo Biolaboratories

anti-GABAA Receptor beta 3 phospho (Ser408 / Ser409) antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

Gabrb3

gamma-aminobutyric acid type A receptor subunit beta 3

GABA(A) receptor subunit beta-3; GABA-alpha receptor beta-3 subunit; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; Gamma-aminobutyric acid receptor beta 3; gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid type A receptor beta 3 subunit; testis gamma-aminobutyric acid receptor subunit beta 3

Rabbit

IgG

Phosphorylated

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. Phosphorylation of serine 408 and serine 409 within the beta3 subunit have been shown to be critical for the functional modulation of beta3 containing recombinant receptors (Brandon et al., 2000).

Bovine, Canine, Chicken, Human, Mouse, Primate, Rat, Xenopus, Zebra Fish

-20°C

12352203