anti-GATA3, Rabbit Monoclonal (RM482)

RevMAb Biosciences

anti-GATA3, Rabbit Monoclonal (RM482)

10

This antibody reacts to human GATA3 and may also react to mouse or rat GATA3, as predicted by immunogen homology.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM482

GATA3

GATA binding protein 3

GATA-binding factor 3; HDR; HDRS; trans-acting T-cell-specific transcription factor GATA-3

Rabbit

IgG

Trans-acting T-cell-specific transcription factor GATA-3

GATA3 functions as a major regulator of T helper 2 (Th2) cell differentiation in immune cells. GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediated pathway, which results in production of IL-4, IL-5, and IL-13 cytokines, responsible for preferential differentiation of Th2-cells. GATA3 has been shown to regulate early developmental processes of T cells, such as T cell commitment, positive selection, and post-commitment CD4+ T cell survival. GATA3 coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL-33. Upon tissue injury, acts downstream of IL-33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. GATA3 has been reported to be essential in the development of a variety of normal tissues. Defect in GATA3 results in hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR syndrome). - Recombinant Antibody. This antibody reacts to human GATA3 and may also react to mouse or rat GATA3, as predicted by immunogen homology. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to human GATA3. Applications: IHC, WB. GATA3 functions as a major regulator of T helper 2 (Th2) cell differentiation in immune cells. GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediated pathway, which results in production of IL-4, IL-5, and IL-13 cytokines, responsible for preferential differentiation of Th2-cells. GATA3 has been shown to regulate early developmental processes of T cells, such as T cell commitment, positive selection, and post-commitment CD4+ T cell survival. GATA3 coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL-33. Upon tissue injury, acts downstream of IL-33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. GATA3 has been reported to be essential in the development of a variety of normal tissues. Defect in GATA3 results in hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR syndrome).

Human, Mouse, Rat

-20°C

12352203