Anti-GDF15 [Clone 29]

Absolute Antibody

Anti-GDF15 [Clone 29]

9

This antibody binds the human growth/differentiation factor 15 (GDF-15) also known as macrophage inhibitory cytokine 1. GDF-15 is a divergent member of the transforming growth factor-beta (TGF-beta) superfamily. While physiological expression is barely de

This antibody can detect human GDF-15 protein in an ELISA and western blot. This antibody significantly reduces the neovascularization of endothelial cells produced by the GDF-15 protein. It also inhibits the growth of skin cancer, colon cancer, breast cancer or prostate cancer, pancreatic cancer, liver cancer, gastric cancer, inhibits angiogenesis inside/outside these tissues and inhibits the proliferation of cancer cells. The angiogenesis inhibitory activity was first confirmed in vitro through the tube formation assay and aortic ring branching assay. The inhibitory activity of this antibody was also tested in an in vivo angiogenesis assay using chick chorioallantoic membrane (CAM). It was reported that this antibody can inhibit angiogenesis in vivo to an excellent degree. This antibody is recommended for diagnosis of disease where GDF-15 is overexpressed (WO2019004550).

Functional Assay, Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Clone 29

GDF15

growth differentiation factor 15

GDF-15; growth/differentiation factor 15; macrophage inhibitory cytokine 1; MIC1; MIC-1; NAG-1; non-steroidal anti-inflammatory drug-activated gene-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; placental bone morphogenetic protein; placental TGF-beta; prostate differentiation factor; PTGFB; PTGF-beta

Rabbit

IgG

Growth/differentiation factor 15

Human

-20°C,2°C to 8°C

12352203