Anti-Genome polyprotein [1D5], Mouse Fab fragment, His-Tagged, kappa

Absolute Antibody

Anti-Genome polyprotein [1D5], Mouse Fab fragment, His-Tagged, kappa

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This antibody is specific for the immune-dominant antigenic site within VP1 comprising the BC, DE, EF, and HI loops of Coxsackievirus A6. It does not show the same reactivity in other Coxsackievirus variants.

The original antibody was used for immunohistochemistry on Coxsackievirus A6 infected mice. Further this antibody was used for an in vivo neutralization assay on BALB/c mice. The BALB/c mice were passively immunized with this antibody before being infected with Coxsackievirus A6. This significantly increased survival rates. This antibody was also used for a neutralization assay where the mouse was first infected with Coxsackievirus A6 before injecting this antibody. This also increased survival rates (Yang et al., 2016; PMID:27582066). This antibody was used for an in vitro neutralization assay, the binding of Coxsackievirus A6 to RD cells was tested and showed a decrease compared to the control. This antibody was used for an ELISA on Coxsackievirus A6 particles. The structure of this antibody was determined using Cryo-EM (Xu et al., 2017; PMID:28894095).

ELISA, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

1D5

Mouse

Virus

-20°C,2°C to 8°C

12352203