Anti-Ghrelin [1621]

Absolute Antibody

Anti-Ghrelin [1621]

9

The antibody has specificity for both the acylated and unacylated form of ghrelin.

ELISA demonstrated that 1621 binds full length human ghrelin independent of its acylation status, and binds poorly to rat ghrelin. The in vitro FLIPR Calcium Assay system was used to show that 1621 binds residues 4-20 of human ghrelin. Using SPR, the Kd of 1621 binding to acylated human ghrelin was determined as 6.80 x 10^-10 M; the Kd of 162 binding to deacylated human ghrelin was determined as 1.74 x 10^-9 M.

1621

GHRL

ghrelin and obestatin prepropeptide

appetite-regulating hormone; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin preprohormone; ghrelin/obestatin prepropeptide; growth hormone-releasing peptide; In2c-preproghrelin; motilin-related peptide; MTLRP; prepro-appetite regulatory hormone; preproghrelin

Appetite-regulating hormone

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse Fab format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203