Anti-Glomerular antigen [E5-1]

Absolute Antibody

Anti-Glomerular antigen [E5-1]

9

This antibody displays polyreactive binding to GA, ssDNA, dsDNA and IgG. It does not bind histones or Sm proteins.

The binding specificity of this antibody has been confirmed in ELISA and Western blot analysis (Sekine et al, 2004). Intravenous administration of this antibody to normal mice results in glomerular binding, as revealed by immunofluoescence analysis, suggesting that the production of glomerular-binding autoantibodies by renal mononuclear cells conributes to the developmet of lupus nephritis (Sekine et al, 2004).

ImmunoFluorescence, Western Blot, ELISA

Research Use Only

Monoclonal

E5-1

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203