Anti-Glucose-dependent insulinotropic Receptor [Gipg013]

Absolute Antibody

Anti-Glucose-dependent insulinotropic Receptor [Gipg013]

9

The original has a Ki value of 7 nM and a Kd value of 6.8 nM for human GIPr.

This antibody binds to GIPr, a GPCR expressed on pancreatic beta-cells, where activation leads to the release of insulin. Endogeonous ligands for the receptor include oleylethanolamide and lysophosphatidylcholine. The antibody acts as a competitive antagonist. In rat islets, the antibody inhibits GIP-induced secretion of insulin by up to 81%.

ImmunoFluorescence, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Gipg013

GPR119

G protein-coupled receptor 119

glucose-dependent insulinotropic receptor; GPCR2; G-protein coupled receptor 2

Rabbit

IgG

Glucose-dependent insulinotropic receptor

This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.

Canine, Human, Mouse, Rat

-20°C,2°C to 8°C

12352203