Anti-Glycoprotein D of HSV [Fd138-80]

Absolute Antibody

Anti-Glycoprotein D of HSV [Fd138-80]

9

This antibody recognizes and binds a shared epitope of glycoprotein D (gD) of HSV1 and HSV2.

This antibody protected mice against encephalitis and death following ocular inoculation with the virus. Murine Fd138-80 has been shown to neutralize HSV-1 in vitro without complement. Humanized and murine Fd138-80 were able to cause a 90% plaque reduction at an antibody concentration of 7 nM (1 ug/ml) (PMID: 3010559, 3030642, 2838428). The binding of antibody to HSV-infected Vero cells was tested using fluorocytometry. Immunostaining was used to view Vero cell monolayers infected with HSV-1 and total cell lysis in the presence of Fd138-80. Humanized version of this antibody has similar affinity as compared to its murine version (PMID: 1849279).

Flow Cytometry, ImmunoFluorescence, Neutralisation/Blocking

Research Use Only

Monoclonal

Fd138-80

US6

envelope glycoprotein D

envelope glycoprotein D; HHV1gp00p09

Rabbit

IgG

Envelope glycoprotein D

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203