Anti-Glypican 3 [AB13E3]

Absolute Antibody

Anti-Glypican 3 [AB13E3]

9

This antibody binds human glypican 3 (GPC3).Glypican-3 is an oncofetal antigen that belongs to the glypican family of glycosyl-phosphatidylinositol-anchored heparin sulfate proteoglycans. It negatively regulates the hedgehog signaling pathway and positive

The binding specificity of this antibody for human glypican 3 was determined using ELISA. The original IgG1 version of this antibody binds human GPC3 with an affinity of Kd = 2.84 pM. This antibody can bind GPC3 expressed on the surface of PLC/PRF/5 and Huh7 cells in an in vitro binding assay. This antibody also positively shows ADCC activity on PLC/PRF/5 cells expressing glypican 3 (CN109988240).

Functional Assay, ELISA

Research Use Only

Monoclonal

AB13E3

GPC3

glypican 3

DGSX; glypican proteoglycan 3; glypican-3; GTR2-2; heparan sulphate proteoglycan; intestinal protein OCI-5; MXR7; OCI-5; SDYS; secreted glypican-3; SGB; SGBS; SGBS1

Human

IgG1

Glypican-3

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203