Anti-Gn [RV-Gn1]

Absolute Antibody

Anti-Gn [RV-Gn1]

9

The antibody is specific for the Gn protein. The antibody is directed to the membrane-distal domain of RVFV Gn.

The specificity of the original format of the antibody was confirmed by ELISA analysis.The antibody was able to able to neutralize RVFV in vitro. A plaque reduction neutralization test (PRNT) demonstrated that the antibody neutralized RVFV with half-maximal inhibitory concentration (IC50) values ranging from 2.1 to 3.0 microg/mL. The antibody protected against RVFV challenge in a murine infection model. The structure of rift valley fever virus Gn in complex with the Fab fragment of the antibody was determined, revealings that the antibody targeted to the membrane-distal head region of RVFV Gn (Allen et al., 2018; PMID: 30590046).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

RV-Gn1

Rabbit

IgG

Envelopment polyprotein

Virus

-20°C,2°C to 8°C

12352203