Anti-GPIIB/IIIA [PDG7]

Absolute Antibody

Anti-GPIIB/IIIA [PDG7]

9

PDG7 does not bind to antigen denatured by heat of pH, indicating the necessity of intact GPIIb/IIIa.

Dot blots confirmed the specificity of PDG7 for GPIIB/IIIA. Inhibition assays were used to show that platelet-associated autoantibodies from AITP patients binds a closely related epitope to that of the recombinant anti-GPIIb/IIIa phage clones (Escher et al, 1998). Inhibition studies also confirmed that PDG7 inhibited binding of eluted platelet-associated autoantibodies from AITP patients to platelets (Escher et al, 1998).

Dot Blot, Neutralisation/Blocking

Research Use Only

Monoclonal

PDG7

Human

IgG1

This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203