anti-H-Ras antibody [H-RAS-03]

Arigo Biolaboratories

anti-H-Ras antibody [H-RAS-03]

23

Western Blot

Research Use Only

Monoclonal

H-RAS-03

1 mg/ml

Unconjugated

>95%

HRAS

HRas proto-oncogene, GTPase

C-BAS/HAS; C-HA-RAS1; c-has/bas p21 protein; C-H-RAS; CTLO; GTP- and GDP-binding peptide B; GTPase HRas; HAMSV; Ha-Ras1 proto-oncoprotein; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; HRAS1; H-RASIDX; p19 H-RasIDX protein; p21ras; Ras family small GTP binding protein H-Ras; RASH1; transformation gene: oncogene HAMSV; transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Mouse

IgG1

H-Ras is one of three ubiquitously isoforms of Ras GTPase that operate at the intracellular leaflet of the plasma membrane to regulate multiple signal transduction pathways, such as mitogen-activated protein kinase (MAPK) cascade. H Ras is anchored to the plasma membrane by farnesyl and two palmityl residues. GTP loading decreases H-Ras affinity for lipid rafts and allows the protein to target to nonraft microdomains, the primary sites of H-Ras signaling. Sos protein and other guanine nucleotide-exchange factors catalyze dissociation of GDP from Ras. Besides its roles in the plasma membrane, active H-Ras also diffuses through the cytoplasm on nanoparticles termed rasosomes, which is dependent on Ras palmitoylation.

Human

-20°C

12352203