Anti-HA [Mab 3.1]

Absolute Antibody

Anti-HA [Mab 3.1]

9

The antibody recognizes the conserved heterosubtypic epitope in the stem of influenza A virus hemagglutinin. The epitope consists of residues from the N- and C-terminal regions of HA1 (38, 40 to 42, 289 to 293, and 318) and the N-terminal portion of HA2 (

In ELISAs, the Fab fragment was found to bind to recombinant HA protein. The Fab fragment neutralized viruses of the H1, H2, H5, and H6 subtypes at half-maximal inhibitory concentrations in the ug/ml range. Passive immunization with the Fab fragment protected mice from a lethal challenge with A/Puerto Rico/8/1934(H1N1) virus. The crystal structure of the antibody in complex with HA from a pandemic H1N1 influenza virus was determined.

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

Mab 3.1

Human

Virus

-20°C,2°C to 8°C

12352203