Anti-HBV pre-S1 protein [MA18/7]

Absolute Antibody

Anti-HBV pre-S1 protein [MA18/7]

9

This antibody binds a clearly defined epitope DPAF (amino acids 31-34) of the pre-S1 region of the hepatitis B virus. Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It can cause chronic infection and p

This antibody can be used for the identification of HBV pre-S2 protein using immunoblot and western blot (PMID: 6492255). The original mouse IgG1 version of this antibody was reported to bind pre-S1 protein of HBV with a binding affinity of Kd= 0.24 nM (PMID: 10509818). Immunoblot analysis revealed that the tetrapeptide Asp-Pro-Ala-Phe (DPAF), located at the position preS(31-34) and conserved in all known HBV genomes, is sufficient to bind MA18/7 antibody (PMID: 1279369). It was reported that MA18/7 inhibits the binding of natural HBV to hepatocyte membranes (PMID: 7964611). This antibody has shown to neutralize infectivity of HBV for primary human hepatocytes, also blocked infection of primary Tupaia belangeri hepatocytes (PMID: 12915565).

Functional Assay, Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

MA18/7

Rabbit

IgG

Virus

-20°C,2°C to 8°C

12352203