Anti-HCMV gH [HCMV16]

Absolute Antibody

Anti-HCMV gH [HCMV16]

9

This antibody binds gpUL75 (gH) of the human cytomegalovirus, which is an 86-kDa glycoprotein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. It is though t

This antibody successfully precipitates glycoprotein H from both HCMV infected cell lysates and HCMV-gH-VAC-infected cell lysates. Cellular localization of HCMV-gH studied by immunofluorescence on recombinant vaccinia virus and HCMV-infected cells using HCMV-16. HCMV-16 strongly neutralizes HCMV infectivity in vitro (PMID: 2831402). The reshaped humanized antibody recognized cells infected with a variety of virus strains and neutralized clinical isolates of CMV as efficiently as laboratory strains in a conventional plaque reduction assay (PMID: 9207350).

ImmunoFluorescence, ImmunoPrecipitation, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

HCMV16

Mouse

IgG1

Virus

-20°C,2°C to 8°C

12352203