Anti-HER2/ErbB2 Mouse mAb

PTM BIO

Anti-HER2/ErbB2 Mouse mAb

5

Western Blot

WB

Antibody

Research Use Only

Monoclonal

13407

Unconjugated

Mouse

IgG

Receptor tyrosine-protein kinase erbB-2

The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. One of which is erbB-2, and the other members being epidermal growth factor receptor, erbB-3 (neuregulin-binding; lacks kinase domain), and erbB-4. All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. Notably, no ligands for HER2 have yet been identified. HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. Dimerisation results in the autoPhosphorylatedrylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203