Anti-hINSR [IR 18-34]

Absolute Antibody

Anti-hINSR [IR 18-34]

7

This antibody recognises the extracellular domain of human INSR. It does not cross-react with rat, mouse or rabbit insulin receptors, and displays very low cross-reactivity with bovine, porcine and ovine INSR.

This antibody has been used in immunoprecipitation assays, with both radiolabelled human insulin receptor (hINSR) and hINSR-radiolabelled insulin complexes (Soos et al, 1986). This antibody has also been used in immunoblot analysis with purified hINSR (Soos et al, 1986) and immunohistochemistry. This antibody has been shown to have limited inhibitory effect on insulin binding to IM-9 cells (Soos et al, 1986). However, this antibody has been shown to stimulate insulin receptor autophosphorylation and kinase activity towards exogenous substrates (OBrien et al, 1987).

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

IP; IB; IHC

Research Use Only

Monoclonal

IR 18-34

INSR

insulin receptor

CD220; HHF5; insulin receptor; IR

Rabbit

IgG

Insulin receptor

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised by immunising BALB/c mice with purified human placental insulin receptor.

-20°C,2°C to 8°C

12352203